hrcA [2017-8-11 16:0:3]

transcriptional repressor of class I heat-shock genes

Locus: BSU25490

Isoelectric point: 6.08

Molecular weight: 38.87 kDa

Protein length: 343 aa

Gene length: 1029 bp

Function: regulation of chaperone gene expression

Product: transcriptional repressor

Essential: no

Synonyms: yqxE,yqeS

Genomic Context

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Categories containing this gene/protein

• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other
• Lifestyles → Coping with stress → Heat shock proteins
• Groups of genes → Phosphoproteins → Phosphorylation on an Arg residue

Gene

Coordinates: 2,628,606 → 2,629,637

The protein

Catalyzed reaction/ biological activity

• transcription repressor of the hrcA-grpE-dnaK-dnaJ-yqeT-yqeU-yqeV and groES-groEL operons (at low/ normal temperatures)

Protein family

• hrcA family (according to Swiss-Prot)

Modification

• phosphorylated on arginine residues PubMed

Cofactors

• GroEL acts as co-repressor

Localization

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• Genes: hrcA-grpE-dnaK-dnaJ-yqeT-yqeU-yqeV
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • HrcA: repression, PubMed, in HrcA regulon

  Regulation

  • induced by heat shock (HrcA) PubMed

Labs working on this gene/protein

• Wolfgang Schumann, Bayreuth University, Germany Homepage
• Thomas Wiegert, University of Bayreuth, Germany Wiegert-Dateien/Thomas Wiegert.html Homepage

References

Reviews

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Original Publications

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